In this video abstract, Schobel et al. describe progressive functional and structural abnormalities of the hippocampus observed in MRI studies of patients who progress to psychosis and mice exposed to...
A New Strategy for Treating Neuropathic Pain - Conventional methods of pain treatment have often proved ineffective in the treatment of neuropathic pain. Here, in an effort to develop a new therapeuti...
Context- and Output Layer-Dependent Ensemble Plasticity in the OB
Context- and Output Layer-Dependent Ensemble Plasticity in the OB. Using chronic imaging in awake behaving mice, Yamada, Bhaukaurally et al. discovered two distinct forms of long-term ensemble plastic...
Synapses are formed with high degree of specificity in our brain. In this VIDEO, Kang Shen and Kota Mizumoto describes "synaptic tiling" as a way to precisely organize the subcellular locati...
A Mouse Model for Mitochondrial Deafness - Why do mitochondrial diseases often affect very specific tissues, such as cells in the inner ear? Gerald Shadel's mouse model reveals how mitochondrial stres...
NMDA Receptor Signaling Critical for Habit Formation
NMDA Receptor Signaling Critical for Habit Formation - How does the brain form habits? Joe Tsien and colleagues explore the cellular mechanisms underlying habit formation and find that NMDA receptors ...
Human and mouse pluripotent stem cells can differentiate into all cell types within adult bodies, but they have limited potential to differentiate into extraembryonic tissues such as placenta and yolk...
Blebs on the Move - Erez Raz and his colleagues use a tour through their lab to walk you through the approach they took to analyzing the migratory behavior of primordial germ cells in vivo....
Jeannie Lee and colleagues show that the X-linked Jpx noncoding RNA antagonizes the autosomally encoded CTCF transcription factor by titrating it away from the Xist promoter during X chromosome inacti...
