Memory Enhancement by Targeting NR2B Cell Surface Regulation
Many neurological disorders, such as Alzheimer's disease, are characterized by learning and memory deficits, for which cognitive enhancement is considered a valid treatment strategy. Plattner and coll...
Amyloids Stick It to Cellular Machines - Amyloids knock out key protein "hubs" by sequestering them in aggregates, explain Ulrich Hartl and colleagues. Does this toxicity contribute to prote...
Orchestrated amplification and differentiation of intermediate progenitors governs the evolutionary expansion of the cerebral cortex. Fang et al. report that Axin serves as a master scaffold that dete...
Where and How Is Motor Memory Stored?/Cell October 27, 2016 (Vol. 167, Issue 4)
Where and How Is Motor Memory Stored?/Cell October 27, 2016 (Vol. 167, Issue 4) - Have you ever wondered why you lost appetite when sick? Maybe it is your body's way to tell you not to eat certain foo...
A Sticky Wicket: Opposing Functions of p120-Catenin in Development and Cancer
A Sticky Wicket: Opposing Functions of p120-Catenin in Development and Cancer - Albert Reynolds discusses how his group came to examine the role of p120-catenin in the mouse salivary gland and the imp...
In this video abstract, the authors discuss their article "The Evolution of Epigenetics: from Prokaryotes to Humans and its Biological Consequences", recently published in Genetics & Epi...
Cav1 Shapes the Matrix to Guide Metastasis - Miguel del Pozo and team members show us how stromal fibroblasts can guide tumor cell migration by stretching the matrix into ordered tracks. Mutating Cav1...
Variance as a Signature of Neural Computations - Can the variability of neural responses provide insight into mechanisms of decision making? Anne Churchland and co-authors have developed a technique t...
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis - Pietro De Camilli discusses how his group came to define the F-BAR domain and its role in endocytosis, and where subseque...