Chemokine Signaling Regulates Tau Pathology - Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are a hallmark of tauopathies. In this video abstract, Bruce Lamb and coll...
miRNA Decoy in Tumor Suppression - miRNAs are known to downregulate target mRNAs by complementary base pairing, but there's more to the story. Watch and listen as Danilo Perrotti and Anna Eiring take ...
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors. In this study, Kim and Zhang et al. dissect a genetically defined circuit for appetitive behaviors from the basolateral amygda...
Nucleosomal Elements that Control the Topography of the Barrier to Transcription
Carlos Bustamante and colleagues explain how different nucleosomal components combine together to create physical impediments to transcription that RNA Pol II must overcome in order to successfully tr...
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis - Pietro De Camilli discusses how his group came to define the F-BAR domain and its role in endocytosis, and where subseque...
Caveolae Are Stress Sinks for Membranes - Latin for "little caves," caveolae are small folds in the plasma membrane associated with endocytosis.
Now Christophe Lamaze and colleagues outline...
How Does CaMKII Sense Specific Calcium Waves? - John Kuriyan and his team reveal a flower-like unfurling mechanism that allows different isoforms of CaMKII to sense particular frequencies of calcium s...
