Spatial and Temporal Dynamics of the AMPA Receptor Proteome
Spatial and Temporal Dynamics of the AMPA Receptor Proteome. Native AMPA receptors are macromolecular complexes assembled from a total of more than 30 different constituents that determine architectur...
Remote Control of pmCRY2 Exponential Gradients - TIRF mCherry images of a HeLa cell transfected with CRY2-mCherry and CIBN-GFP and plated on a round pattern of fibronectin. The area of activation is r...
Imaging Clock Oscillations in the Mouse Embryo - The periodic, anteriorly traveling waves of cyclic gene expression can be seen in the presomitic mesoderm (PSM) of a transgenic mouse embryo. The trans...
Induced Neurons Recapitulate Cellular Phenotypes of an Autism Spectrum Disorder
Induced Neurons Recapitulate Cellular Phenotypes of an Autism Spectrum Disorder - Alysson Muotri and colleagues derive neurons from Rett patients' fibroblasts and then pharmacologically rescue defects...
Leaving Trash with Moms Keeps Daughters Young - In budding yeast, damaged and aggregated proteins segregate into the mother cell during cell division, leaving the newly budded daughter with a fresh st...
Membrane Tension Maintains a United Front - Using his own neutrophils, Orion Weiner demonstrates how physical forces and not diffusible factors ensure that migrating cells have a single leading edge....
DeCoN: High-Throughput Investigation of the Cortical Transcriptome
DeCoN: High-Throughput Investigation of the Cortical Transcriptome - Decoding the signals that shape and maintain the extraordinary neuronal diversity of the mammalian cortex remains a challenge. In t...
Andres Hidalgo and colleagues discover that the clearance of aged neutrophils from the circulation by macrophages in the bone marrow is coupled to the systemic egress of hematopoietic precursors from ...
External genital anatomy evolves rapidly and is remarkably diverse among animals that reproduce by internal fertilization. One of the most intriguing evolutionary transitions is the reduction and loss...
It is not clear how the prefrontal cortex integrates diverse inputs during the regulation of emotional responses. In an effort to gain insight into the neural circuitry underlying the expression of co...
