Blood-Brain Barrier Breakdown and Cognitive Impairment in Humans

Blood-Brain Barrier Breakdown and Cognitive Impairment in Humans - By imaging the living human brain, Montagne et al. show an age-dependent blood-brain barrier (BBB) breakdown in the hippocampus, a region critical for learning and memory, which worsens with mild cognitive impairment and correlates with injury to BBB-associated cell pericyte.