Breaking Bcr-Abl Resistance - Giulio Superti-Furga discovers a new vulnerability of drug-resistant Bcr-Abl mutants—blocking their SH2 domain interface enhances the effectiveness of tyrosine kinase inh...
Translaminar Inhibitory Cells Recruited by Layer 6 Cortico-Thalamic Neurons
This Neuron video abstract describes a cortical pathway by which layer 6 cortico-thalamic neurons suppress cortical responses to visual stimuli. These neurons recruit fast-spiking inhibitory cells in ...
Figure360: Trends in Biotechnology, Johannssen and Lepenies, Figure 3
Glycan-Based Cell Targeting To Modulate Immune Responses. Glycosylation is an integral post-translational modification present in more than half of all eukaryotic proteins. It affects key protein func...
Shedding Light on Hippocampus-Amygdala Communication
Shedding Light on Hippocampus-Amygdala Communication - Bazelot et al. dissect synaptic mechanisms orchestrating the information flow from the ventral hippocampus to the amygdala, two regions of the li...
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors. In this study, Kim and Zhang et al. dissect a genetically defined circuit for appetitive behaviors from the basolateral amygda...
PARP around the Clock - Circadian rhythms are entrained with feeding schedules. Watch as Gad Asher takes you on a brief, personally guided tour of his discovery that nutrient intake regulates the osci...
Leaving Trash with Moms Keeps Daughters Young - In budding yeast, damaged and aggregated proteins segregate into the mother cell during cell division, leaving the newly budded daughter with a fresh st...
Jeannie Lee and colleagues show that the X-linked Jpx noncoding RNA antagonizes the autosomally encoded CTCF transcription factor by titrating it away from the Xist promoter during X chromosome inacti...
Thalamic Mechanism of Parkinson Disease. Hyper-inhibition of thalamic neurons by the basal ganglia inputs has been proposed as a mechanism for Parkinson's disease. This study shows that rebound firing...
