Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Hao Wu and colleagues describe how inflammasome assembly brings sensor proteins together through polymerization....

Alpha Helix to Beta Barrel Switch Transforms Transcription Factor RfaH to Translation Factor

Alpha Helix to Beta Barrel Switch Transforms Transcription Factor RfaH to Translation Factor. Paul Rösch describes the remarkable transformation of a transcription factor into a translation factor th...

Wetlands and nutrient retention

Wetlands and nutrient retention in the Baltic Sea...

YouTube Science Video

Richard Lee, Amy Wagers, and colleagues describe their parabiosis experiments in mice, which helped unravel a role for the TGF-beta family member GDF-11 as a negative regulator of age-associated cardi...

Portabella: A New Player in Neurotransmission

Portabella: A New Player in Neurotransmission - David Krantz and colleagues report the discovery of portabella, a Drosophila gene that is structurally similar to known vesicular transporters and is ex...

Myosin Shows a Transient Apical Enrichment Prior to Apical Clearing in Wild-Type Neuroblasts

Myosin Shows a Transient Apical Enrichment Prior to Apical Clearing in Wild-Type Neuroblasts ...

S. aureus Alpha Toxin Induces Platelet Aggregation in Various Vascular Beds

S. aureus Alpha Toxin Induces Platelet Aggregation in Various Vascular Beds ...

Why Don't We All Get Alzheimer's Disease?

Why don't we all get Alzheimer's disease? Roy and colleagues stumbled on a possible reason why we all don't get Alzheimer's disease even though we all have the basic ingredients essential for getting ...

Bite Force of the Living Coelacanth

Bite Force of the Living Coelacanth - YouTube...

Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration

Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration ...

Drosophila CNS Glutamate Receptors Break the Rules

Using structural and electrophysiological techniques Li, Dharkar et al. find that Drosophila CNS glutamate receptors have unexpected ligand selectivity. The kainate receptor DKaiR1D is inhibited by NM...

Semantic Representation in the Human Brain

How are distinct action and object categories represented in the human brain? Alexander Huth, Jack Gallant, and colleagues examined the representation of 1,705 object and action categories in the huma...

The 1%: VIP Cells Control Brain Development

The 1%: VIP Cells Control Brain Development ...

Developmental Cell Burkel/Bement video abstract

The non-imaging-forming visual system has important physiological roles, including entrainment of the circadian rhythm, but its development is not well understood. Here, Andrew Lumsden and colleagues ...

Editor at a Conference: A Balance between Formal and Social

Editor at a Conference: A Balance between Formal and Social - YouTube...

Revitalizing Our View of Heart Development

Revitalizing Our View of Heart Development - Robert Kelly discusses the historical context for the work, outlines how research into the second heart field has progressed in the interim, and highlights...

Untangling Chromosomes

Untangling Chromosomes - Homologous chromosomes find each other and align correctly during meiosis with the help of the cytoskeleton, new work by Dernburg and colleagues shows. Watch and listen as Abb...

Specialized Sensory Neurons for Hair Pull Pain

Specialized Sensory Neurons for Hair Pull Pain ...

Endophilin beyond Endocytosis

Endophilin beyond Endocytosis - Endophilin A1 is known to play a role in the endocytosis of synaptic vesicles. Now, Christian Rosenmund and colleagues find that it contributes to synaptic vesicle exoc...

Excess Membrane Synthesis Drives a Primitive Mode of Cell Proliferation

Jeff Errington and colleagues discover that increased membrane surface area, a simple biophysical change, in wild-type protoplasts drives L-form-like division, providing a model for evolution of early...