Smart T Cell Vaccines: CAR T Cells - by Carl June, MD Erika Pearce and colleagues challenge previous ideas about T cell metabolism by showing that activated T cells switch from oxidative phosphorylation to aerobic glycolysis not to promote proliferation but instead to augment the production of the antimicrobial protein IFN-γ, which is regulated by the glycolytic enzyme GAPDH. Contributed by: David Simmons
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