Bruchpilot Acetylation Influences Active Zone Structure

Bruchpilot Acetylation Influences Active Zone Structure - Patrik Verstreken and co-authors find that in addition to acetylating histones in the nucleus, the histone acetyl-transferase ELP3 plays a role at the synapse where it acetylates the active zone-associated protein Bruchpilot. Lack of ELP3 leads to defects in active zone morphology and altered neurotransmitter release, which suggests that ELP3-dependent acetylation of Bruchpilot may be fundamental Video maintaining the structural...