A Conformational Twist for GPCR Signaling/ Cell, October 6, 2016 (Vol.. 167, Issue 3)

A Conformational Twist for GPCR Signaling/ Cell, October 6, 2016 (Vol.. 167, Issue 3) - G protein-coupled receptor (GPCR) signaling, mediated by hetero-trimeric G proteins, can be differentially controlled by agonists. At a molecular level, this is thought to occur principally via stabilization of distinct receptor conformations by individual ligands.