Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down

Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down - By trapping Mre11-Rad50 in mulitple states, Karl-Peter Hopfner and colleagues discover that Mre11-Rad50 transiently assembles into an ATP-controlled DNA clamp that recognizes double-strand breaks, even those breaks covalently blocked by proteins.