Localized Axonal Translation in Retrograde Injury Signaling

Local translation in dendrites is known to have important physiological roles, but so far evidence is lacking for an essential role of mRNA localization in axons. In this study, Mike Fainzilber and colleagues discovered that localized translation of axonal importin β1 mRNA is required for efficient retrograde signaling in injured axons. For more information, see Perry et al., Neuron 75(2).