Dopamine: Motivation, Salience and Learning - A Genetic Perspective
Decision making is impacted by risk. Masaaki Ogawa and colleagues in the laboratory of Geoffrey Schoenbaum find that activity of risk-responsive neurons in the orbitofrontal cortex track salience bett...
Risky Decisions: A Role for Rostrolateral PFC - How do we decide between the familiar and the unknown? David Badre, Michael Frank, and colleagues find that the pattern of neural activity in rostrolate...
Ronald Evans and colleagues show that activation of the vitamin D receptor sensitizes the stroma of pancreatic cancers to conventional chemotherapy, boosting its efficacy and survival rates....
A Mouse Model for Mitochondrial Deafness - Why do mitochondrial diseases often affect very specific tissues, such as cells in the inner ear? Gerald Shadel's mouse model reveals how mitochondrial stres...
Guided by the Light: Neutrophil Migration through Zebrafish
Guided by the Light: Neutrophil Migration through Zebrafish - Anna Huttenlocher, with the help of Sa Kan Yoo and Qing Deng, explain their investigation of neutrophil migration through the zebrafish em...
Hierarchical Prediction Errors in Sensory Learning
Prediction errors (PEs) are crucial teaching signals for learning. Here, we show that different precision-weighted PEs map onto distinct neurotransmitter systems: the dopaminergic midbrain signals pre...
Liam Redgrave, Sam Sutton, Mark Webber, and Laura Piddock discuss bacterial resistance to fluoroquinolones. They explore how fluoroquinolones target bacterial type II topoisomerases to interfere with ...
