The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
Ron Germain and colleagues identify the mitochondrial adapter molecule MAVS as a critical regulator of inflammasome activation. They discuss their findings on how MAVS and another adapter, ASC, are bo...
Precision & Plasticity in Mentoring. Angela DePace speaks about “Precision & Plasticity in Mentoring (and animal transcription)” at the Cell Press/AWIS LabLinks meeting on The Gender of Scien...
Multisensory Plasticity in Mothers - How do the physiological changes associated with motherhood influence sensory processing within the mother's brain? In this study, Adi Mizrahi and colleagues find ...
Mitochondrial links to genomic instability in aging
Mitochondrial links to genomic instability in aging - Understanding why our genomes become more prone to mutations as we age is a key goal of ageing and cancer research. Dr. Dan Gottschling and his co...
Dolphins sometimes need pain medications just like people do, but no one has ever looked at how pain medications work in a dolphin’s body before. We gave ten bottlenose dolphins a dose of meloxicam, a...
TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets
Lily Jan and colleagues describe their work using TMEM16F knockout mice to discover the mechanism of lipid scrambling at the plasma membrane, an important precursor step in platelet activation during ...
Researchers from Beth Israel Deaconess Medical Center and Yale University describe a new optical method to simultaneously record neuronal activity across all layers of the cerebral cortex -- in a beha...
Am I Losing My Retromer? In this video, Temkin et al. explore a synaptic mechanism for memory failure in Alzheimer’s and Parkinson’s diseases that is dependent on malfunction of an endosomal sorting c...
Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions
John Mekalanos and colleagues describe their surprising findings of the bacterial swordplay that occurs when P. aeruginosa is attacked by a type VI secretion system (T6SS) from a neighboring cell of a...
The Heart as a Metabolic Organ - Eric Olson describes how a drug designed to treat cardiac disease reveals an unexpected role for the heart in whole-body energy homeostasis....
