Drosophila CNS Glutamate Receptors Break the Rules
Using structural and electrophysiological techniques Li, Dharkar et al. find that Drosophila CNS glutamate receptors have unexpected ligand selectivity. The kainate receptor DKaiR1D is inhibited by NM...
Avoiding Ribosome Traffic Jams - Optimization of protein synthesis for efficiency is thought to be highly important for evolutionary fitness. Watch and listen as Yitzhak Pilpel and Tamir Tuller take y...
Ocean 180 -- Innocence by Viral Tagging. Viruses are the most abundant biological entities on the planet with approximately 1030 in the world’s oceans at any time. As such, they play a central role in...
Shaping A Morphogen Gradient
Extracellular BMP-binding proteins, such as Sog, regulate the access of BMP ligands to their signaling receptors. Peluso et al. (Developmental Cell, August 2011) report ho...
Evaluating the Utility of PDE10 Inhibition in Huntington’s Disease
Beaumont et al. demonstrate that acute PDE10 inhibition boosts diminished corticostriatal input and indirect pathway output in symptomatic HD models, despite loss of PDE10. Their data provide rational...
Control of Cerebrovascular Networks Formation by Neural Activity
This video summarizes a study from Dr. Chenghua Gu's laboratory at Harvard Medical School, which demonstrates that sensory-related neural activity influences the formation of brain vascular networks d...
Blood-Brain Barrier Breakdown and Cognitive Impairment in Humans
Blood-Brain Barrier Breakdown and Cognitive Impairment in Humans - By imaging the living human brain, Montagne et al. show an age-dependent blood-brain barrier (BBB) breakdown in the hippocampus, a re...
