Functional cycle of the clamp-loader AAA+ ATPase

The asymmetrical clamp-loader pentamer (green, with pink ATP) spirals around a DNA double helix (yellow) and binds the sliding-clamp trimer (brown) around the DNA in an open lock-washer position....

Endophilin beyond Endocytosis

Endophilin beyond Endocytosis - Endophilin A1 is known to play a role in the endocytosis of synaptic vesicles. Now, Christian Rosenmund and colleagues find that it contributes to synaptic vesicle exoc...

Reefs Of Anilao: 2011 Philippine Biodiversity Expedition | California Academy of Sciences

Reefs Of Anilao: 2011 Philippine Biodiversity Expedition | California Academy of Sciences - YouTube...

L. pneumophila Makes Contacts with Mitochondria of Infected Macrophages

L. pneumophila Makes Contacts with Mitochondria of Infected Macrophages ...

Reverse Replay and Reward

Reverse Replay and Reward ...

Neurons Tell the Vessels When to Grow

Neurons Tell the Vessels When to Grow - Yoshiaki Kubota and colleagues show how neurons in the retina titrate local VEGF levels and limit the growth of blood vessels to ensure an appropriate level of ...

p53's Hit Men

p53's Hit Men - p53 both activates and represses gene expression to defend against tumorigenesis. Watch and listen as John Rinn takes you on a brief, personally guided tour of his lab's findings that ...

Learning Songs with the Help of Dopamine

Learning Songs with the Help of Dopamine ...

Singing Fish, Circadian Rhythms, and Melatonin/ Curr. Biol., Sep. 22, 2016 (Vol. 26, Issue 19)

“Singing” Fish Rely on Circadian Rhythm and Melatonin for the Timing of Nocturnal Courtship Vocalization/ Curr. Biol., Sep. 22, 2016 (Vol. 26, Issue 19) - The patterning of social acoustic signaling a...

In Vivo SynapGCaMP6f Imaging at High Magnification with ROI Tracking and Activity Traces

In Vivo SynapGCaMP6f Imaging at High Magnification with ROI Tracking and Activity Traces ...

Why Evolution is True and Why Many People Still Don't Believe It (Jerry Coyne, 2012)

Pardis Sabeti and colleagues describe their analysis of human sequence data from the 1000 Genomes Project to reveal hundreds of potential adaptive variants. In a second study, the authors engineered m...

Sortilin Link to Dementia Pathophysiology

Sortilin Link to Dementia Pathophysiology - Mutation of the gene for PGRN causes Fronto-Temporal Lobar Degeneration but the mechanistic link between reduced PRGN levels and neurodegeneration is unknow...

Recognizing Cancer Antigens/ Cell, Feb. 11, 2016 (Vol. 164, Issue 4)

Recognizing Cancer Antigens/ Cell, Feb. 11, 2016 (Vol. 164, Issue 4) - YouTube...

Rapid Astrocyte Calcium Microdomains

(1) Rapid Astrocyte Calcium Microdomains ...

Birth Defects in Offspring of Women with Pre-Gestational Diabetes

Birth Defects in Offspring of Women with Pre-Gestational Diabetes - Mary Loeken speaks about “Molecular mechanisms responsible for birth defects in the offspring of women with pre-gestational diabetes...

YouTube Science Video

Daniel Colón-Ramos and colleagues explain their surprising findings that CIMA-1, a solute carrier transporter, regulates glial positioning and synaptic maintenance during postdevelopmental growth via ...

Human Mutation - Joseph Casey and Sampath Loganathan

Human Mutation - Joseph Casey and Sampath Loganathan - YouTube...

Postinvasion reactivation of the Shigella flexneri

Postinvasion reactivation of the Shigella flexneri ...

Hearing in a Jumping Spider/ Curr. Biol., Oct. 13, 2016 (Vol. 26, Issue 21)

Hearing in a Jumping Spider/ Curr. Biol., Oct. 13, 2016 (Vol. 26, Issue 21) - Jumping spiders (Salticidae) are famous for their visually driven behaviors [ 1 ]. Here, however, we present behavioral an...

Causal Role of Theta Oscillations in Auditory Working Memory

Causal Role of Theta Oscillations in Auditory Working Memory. This study shows that driving brain oscillations with rhythmic stimulation can specifically improve auditory working memory performance an...