Depolarized Subicular Microcircuits in Epilepsy

Depolarized Subicular Microcircuits in Epilepsy. The subiculum is crucially involved in spreading and generalizing hippocampal seizures. Wang et al. demonstrated depolarized GABAergic signaling caused by the change of chloride transporters in subicular microcircuit mediates secondary generalized seizures in temporal lobe epilepsy in vivo.