Neocortex Recycles Olfactory Cajal-Retzius Cells - The neocortex undergoes extensive developmental growth, but how its architecture adapts to expansion remains largely unknown. Here, we investigated h...
Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging
Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging - Vittorio Sartorelli and Marcella Fulco discuss their identification of a nutrient-sensing pathway that governs the differentiat...
A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in Photoreceptors. Transcription factors often activate and repress different target genes in the same cell. How activation a...
Reef Life of the Andaman (full marine biology documentary)
Coral reef fisheries are an essential resource for millions of people living in the coastal tropics. We show that the structural complexity of coral reef habitats is extremely important for the produc...
Figure360: Trends in Biotechnology, Johannssen and Lepenies, Figure 3
Glycan-Based Cell Targeting To Modulate Immune Responses. Glycosylation is an integral post-translational modification present in more than half of all eukaryotic proteins. It affects key protein func...
Myc and Multiple Myeloma: Drugging the Undruggable
Myc and Multiple Myeloma: Drugging the Undruggable - Reporting a new small-molecule inhibitor of chromatin-binding bromodomains, James Bradner and Constantine Mitsiades offer a back-door route to bloc...
Long-Term Synaptic Depression Triggered by Microglia
Zhang et al. discovered that microglial cells sense inflammatory stimuli and hypoxia in the brain via complement receptor 3 and produce reactive oxygen species (ROS) by NADPH oxidase. The diffusion of...
