Thalamic Mechanism of Parkinson Disease. Hyper-inhibition of thalamic neurons by the basal ganglia inputs has been proposed as a mechanism for Parkinson's disease. This study shows that rebound firing...
Assembly and budding of a virus from a membrane microdomain
Assembly and Budding of a Virus from a Membrane Microdomain - Viruses have an outer protein shell (called a capsid) that surrounds the viral nucleic acid. Enveloped viruses, such as HIV, have an addit...
Jean-Pierre Levraud, Nuno Palha, and Pierre Boudinot discuss how zebrafish can be used as a model for studying viral infections and host-virus interactions. For more information, see the related revie...
Sonic Hedgehog Directs Cortical Circuit Formation - Sonic Hedgehog is one of the most widely studied molecules in developmental biology, with critical functions in tissue patterning, and proliferation...
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis - Pietro De Camilli discusses how his group came to define the F-BAR domain and its role in endocytosis, and where subseque...
This video shows the cross-sectional two-photon microscopy of normal embryos. This is an example of lateral tissue lengthening and shortening in a living embryo....
Hudson and colleagues shed light on ionic bromide, a micronutrient essential for animal life and its importance for the assembly of basement membranes and epithelial tissue development....
Depolarized Subicular Microcircuits in Epilepsy. The subiculum is crucially involved in spreading and generalizing hippocampal seizures. Wang et al. demonstrated depolarized GABAergic signaling caused...
