The asymmetrical clamp-loader pentamer (green, with pink ATP) spirals around a DNA double helix (yellow) and binds the sliding-clamp trimer (brown) around the DNA in an open lock-washer position....
Protons Away for Sperm Activation! - Human sperm are activated to swim more vigorously once they enter the female reproductive tract. Watch and listen as Lishko and Kirichok take you on a brief, pers...
Andy Dillin and colleagues show that, in the nematode worm C. elegans, activation of the unfolded protein response (UPR) regulator XBP-1 in neurons produces a signal that stimulates UPR in intestinal ...
HGP10 Symposium: Biological and Therapeutic Insights from the Cancer Genome - Levi Garraway
Martin Hetzer and colleagues explain how nuclear envelope collapse causes micronuclei breakdown and drives impaired chromosome function. They propose that disrupted microuclei may serve as biomarkers ...
Sulfur for a Long Life - James Mitchell and colleagues describe how dietary restriction prolongs life through the action of endogenously produced hydrogen sulfite....
Mitochondrial links to genomic instability in aging
Mitochondrial links to genomic instability in aging - Understanding why our genomes become more prone to mutations as we age is a key goal of ageing and cancer research. Dr. Dan Gottschling and his co...
