TUBA4A Mutations Are Associated with Familial ALS

TUBA4A Mutations Are Associated with Familial ALS - This video describes the identification of TUBA4A, encoding the Tubulin, Alpha 4A protein, as a novel gene associated with familial ALS through the exome sequencing of hundreds of patients. Functional analyses revealed that TUBA4A mutants lead to a destabilized microtubule network and diminished repolymerization capability. For more details, see the paper in Neuron 84/2,