Cell Surface Topography Is a Regulator of Molecular Interactions
A neutrophil labeled with Alexa-488-conjugated anti-L-selectin spreads onto and engulfs an IL-8-coated glass bead in bright field, epifluorescence, and TIRFM. See the paper by Lomakina et al. in the S...
Switching Gut Microbes On and Off/ Cell, April 20, 2017 (Vol. 169, Issue 3)
The gut microbiota is implicated in numerous aspects of health and disease. In this video and the paper published in the April 20 issue of Cell, Andrew Goodman’s group present a powerful system to mod...
How Curiosity Changes the Brain and Enhances Learning
Charan Ranganath and Matthias Gruber summarize their findings that demonstrate that curiosity changes brain activity within the dopaminergic circuit. Further......
How the Brain Accumulates Evidence during Decision-Making
How the Brain Accumulates Evidence during Decision-Making. Making good decisions requires evidence accumulation, in which newly acquired information is used to update beliefs and select future actions...
Hear Jerson Silva and colleagues discuss their new Opinion article in Trends in Biochemical Sciences, in which they propose that cancer-associated mutant p53 can exert its effects through prion-like b...
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors
Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors. In this study, Kim and Zhang et al. dissect a genetically defined circuit for appetitive behaviors from the basolateral amygda...
The scent of danger: A 70-year-old puzzle solved - When injured, many freshwater fish release an alarm substance that triggers fear in other members of their school. This substance, which is found in ...
Localized Axonal Translation in Retrograde Injury Signaling
Local translation in dendrites is known to have important physiological roles, but so far evidence is lacking for an essential role of mRNA localization in axons. In this study, Mike Fainzilber and co...
Sulfur for a Long Life - James Mitchell and colleagues describe how dietary restriction prolongs life through the action of endogenously produced hydrogen sulfite....
