Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down
Sensing DNA Damage, ATP Orders an Mre11-Rad50 Clamp Down - By trapping Mre11-Rad50 in mulitple states, Karl-Peter Hopfner and colleagues discover that Mre11-Rad50 transiently assembles into an ATP-con...
Specified Neural Progenitors Sort to Form Sharp Domains after Noisy Shh Signaling
Sean Megason and colleagues determine how cells are sorted and spatially organized during development. The authors use live imaging in zebrafish to show that, despite variations in morphogen exposure ...
Waking-like brain function in embryos - When in development do brains "wake up" for the first time? Balaban, Desco, and Vaquero (Current Biology, May 3, 2012) addressed this question using n...
Hearing in a Jumping Spider/ Curr. Biol., Oct. 13, 2016 (Vol. 26, Issue 21)
Hearing in a Jumping Spider/ Curr. Biol., Oct. 13, 2016 (Vol. 26, Issue 21) - Jumping spiders (Salticidae) are famous for their visually driven behaviors [ 1 ]. Here, however, we present behavioral an...
Amyloids Stick It to Cellular Machines - Amyloids knock out key protein "hubs" by sequestering them in aggregates, explain Ulrich Hartl and colleagues. Does this toxicity contribute to prote...
Patients with schizophrenia show decreased activation of the mediodorsal thalamus but it is unclear whether this could generate cognitive deficits. This study shows that a primary decrease in the acti...
Plants Blast Pollinating Passerine Birds with Pollen Clouds
Agnes Dellinger and Florian Etl present the complex bird pollination system of the neotropical treelet Axinaea. Foraging birds activate a bellows organ, which causes the ejection of pollen clouds onto...
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis
F-BAR proteins: Coordinating the effects of actin and dynamin on endocytosis - Pietro De Camilli discusses how his group came to define the F-BAR domain and its role in endocytosis, and where subseque...
Friedhelm Hildebrandt describes how whole-exome resequencing of individuals with ciliopathies reveals mutations in DNA damage response genes, suggesting new pathogenic mechanisms behind this class of ...
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons. Efficient retrograde access to projection neurons for the delivery of sensors and effectors constitutes an important a...
Feedback Control of Vocal Learning - During vocal learning, the ear monitors and instructs the voice. Lei & Mooney examine where auditory feedback processed in the brain and how it modifies motor...
Chemokine Signaling Regulates Tau Pathology - Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are a hallmark of tauopathies. In this video abstract, Bruce Lamb and coll...
Obtaining a clear picture of the proteins that interact with the Huntingtin protein will provide clues for the development of Huntington's disease therapies. In this study, William Yang and colleagues...
How to Inflame Cancer Growth / Cell, July 13, 2017 (Vol. 170, Issue 2)
How to Inflame Cancer Growth. Cancer cells are surrounded by normal cells like fibroblasts and immune cells, but can they be corrupted to promote growth of a tumor? In this video abstract, Andy Minn a...
