B&B: Advanced multivariate data analysis to determine the root cause of trisulfide bond formation...

B&B: Advanced multivariate data analysis to determine the root cause of trisulfide bond formation. Product quality heterogeneities, such as a trisulfide bond (TSB) formation, can be influenced by multiple interacting process parameters. Identifying their root cause is a major challenge in biopharmaceutical production. To address this issue, this paper describes the novel application of advanced multivariate data analysis (MVDA) techniques to identify the process parameters influencing TSB f