When the Break Is Just around the Loop/ Cell, July 27, 2017 (Vol. 170, Issue 3)

When the Break Is Just around the Loop. Inside the nucleus, DNA is packed in highly complex structures that help to control which genes are on and off each time. In this video abstract, Andre Nussenzweig and his colleagues explain how this intricate architecture makes specific DNA sites more susceptible to breaks that, if not properly fixed, can lead to cancer.