Figure360: Cell Chemical Biology, Gayvert et al., Figure 1

A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials. Over the past decade, the rate of drug attrition due to clinical trial failures has risen substantially. Unfortunately it is difficult to identify compounds that have unfavorable toxicity properties before conducting clinical trials. Inspired by the effective use of sabermetrics in predicting successful baseball players, we sought to use a similar “moneyball” approach that analyzes overlooked features to predict clin