Yet Another Facet to Type I Interferon: Kiss of Death to Hepatocytes

Yet Another Facet to Type I Interferon: Kiss of Death to Hepatocytes - The liver is the target of many hepatitis viruses, which affect more than 500 million people worldwide and manifest with a complex pathogenesis. In their Immunity paper, Bergthaler and colleagues identified an unexpected effect of the potent antiviral molecule type I interferon in the liver. Interferon signaling results in the suppression of the key antioxidant superoxide dismutase 1 and the accumulation of reactive oxygen sp