Shedding Light on HCN Channel Gating

Shedding Light on HCN Channel Gating - The mechanism underlying HCN channel activation, including the relative contributions of membrane voltage and the ligand cAMP, is unknown. Klaus Benndorf and colleagues take you on a personally guided tour of their finding that voltage-dependent activation of HCN2 enhances cAMP binding, indicating that these two activation modes are interdependent. Read more in Kusch et al., Neuron 67(1).