Synapse Number Regulates Alcohol Sensitivity

Synapse Number Regulates Alcohol Sensitivity - Alcohol-related problems are associated with reduced sensitivity to alcohol. Eddison et al. find that arouser (aru), a predicted adaptor protein, functions in neurons during development to reduce alcohol sensitivity in Drosophila. The regulation of alcohol sensitivity by the Egfr/Erk and PI3K/Akt pathways requires that aru and aru mutants have increased number of synapses. The increased ethanol sensitivity and synapse number of the aru mutants...