Local Translation Regulates Trigeminal Patterning

Local Translation Regulates Trigeminal Patterning - Retrograde signaling mechanisms contribute to the specification of neuronal identity via regulation of gene transcription in the developing nervous system. Sheng-Jian Ji and Samie R. Jaffrey find that local translation in response to target-derived signals plays a role in regulating specific transcriptional responses during neuron specification in the trigeminal ganglia.