Old Friends with a New Job

Old Friends with a New Job - Drs. Yu Kitadate and Satoru Kobayashi describe their work, building on the original Developmental Cell paper, showing that primordial germ cells use receptor tyrosine kinase ligands to activate a negative feedback mechanism in the embryonic niche. This feedback positions the niche and restricts its size to ensure the appropriate organization and numbers of germline stem cells in the adult fly.