Self-Organized Shuttling: Generating Sharp Dorsoventral Polarity in the Early Drosophila Embryo

Michal Haskel-Ittah describes how he and the Barkai group identified an inhibitor produced simultaneously with active cleaved Spätzle ligand, made up by a new conformation of reassociated N and C termini of the ligand, creating a sharp gradient of Toll receptor activation in the developing embryo.