Corticogenesis from Pluripotent Stem Cells

In this video, Ira Espuny-Camacho and Pierre Vanderhaeghen describe how human pluripotent stem cells can be turned into cortical pyramidal neurons, mimicking key aspects of human corticogenesis. Most strikingly, they show that these human neurons can be transplanted successfully in the mouse neonatal brain, where they integrate specifically and functionally like endogenous cortical neurons. These data provide a unique framework to model human cortical development in health and disease, both in v