Peter Walter (UCSF/HHMI): Unfolding the UPR

Andy Dillin and colleagues show that, in the nematode worm C. elegans, activation of the unfolded protein response (UPR) regulator XBP-1 in neurons produces a signal that stimulates UPR in intestinal cells, improving stress resistance and extending lifespan.

Contributed by: David Simmons

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