Fluoroquinolone resistance in bacteria

Liam Redgrave, Sam Sutton, Mark Webber, and Laura Piddock discuss bacterial resistance to fluoroquinolones. They explore how fluoroquinolones target bacterial type II topoisomerases to interfere with cell division and DNA replication, increases in fluoroquinolone resistance rates found in bacterial infections, global epidemic spread of fluoroquinolone resistant clones as fluoroquinolone resistance can give protection against other antibiotics, and the types of mutations that allow bacteria to be